Despite research suggesting that mutation in ESR1 is an acquired mechanism of resistance to endocrine therapy (ET), the impact of this mutation on therapy response in primary breast cancer remains unclear. To better understand this impact, study investigators analyzed more than 3,200 real-world and population-based early-stage primary breast cancers. Tissues sampled from initial diagnosis, prior to any treatment, were analyzed for the presence of ESR1 mutations using RNA sequencing. ESR1 resistance mutations were identified in 0.9% of cases, of which 1.1% were estrogen receptor-positive. In estrogen receptor-positive disease, presence of ESR1 mutation was significantly associated with poor relapse-free (RFS) and overall survival (OS), and it predicted poor RFS and OS within the patient group who received ET. “We confirm for the first time that such early mutations predict eventual resistance to standard hormone therapy in the adjuvant setting,” write the study authors.
Meeting Coverage
- ASCO – Lung CancerASCO.20 Virtual Scientific Program, held May 29 - 31, brought professionals from all over the world together to hear the brightest minds in oncology present state-of-the-art treatment modalities and new therapies.
- AACR-2020The American Association for Cancer Research is the world's oldest and largest professional association related to cancer research.
- ACC 2020The American College of Cardiology decided to cancel ACC.20/WCC due to COVID-19, which was scheduled to take place March 28-30 in Chicago. However, ACC.20/WCC Virtual Meeting continues to release cutting edge science and practice changing updates for cardiovascular professionals on demand and free through June 2020.
- ENDO: 2020ENDO 2020 Annual Conference has been canceled due to COVID-19. Here are highlights of emerging data that has still been released. Keep an eye out for ENDO Online 2020, which will take place from June 8 to 22.
- CROI 2020Every year, CROI hosts some of the world's leading experts in HIV research, who come to present exciting new data and drive forward the field of HIV/AIDS research. This year, due to COVID-19, CROI held their meeting virtually.
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ASCO 2019The 2019 ASCO Annual Meeting, taking place May 31-June 4 in Chicago, will bring together more than 32,000 oncology professionals from across the globe. The theme of this year’s conference is Caring for Every Patient, Learning From Every Patient.