Antithrombotic and Lipid Lowering Therapy is Associated With Improved Survival After Vascular Surgery: A Population Based Study From Norway.

Oct 23, 2023

Contributors: Martin Altreuther,Arne Seternes,Turi Saltnes,Nadia Myrbø,Kristin Vikan,Linn Hege Nilsen,Tingting Feng

This population based retrospective cohort study aimed to investigate the association of combined treatment with lipid lowering drugs and antiplatelet or anticoagulation therapy and long term survival following vascular surgery in Norway.
This study included all patients who were registered for the treatment of carotid stenosis, abdominal aortic aneurysm (AAA), and atherosclerotic lower extremity arterial disease (LEAD) in the Norwegian Registry for Vascular Surgery between 2015 and 2019 and discharged alive. Clinical and medication details were retrieved from the register. Survival was assessed with Kaplan-Meier analysis and a multivariate Cox regression model. Stratification was according to treatment group, patient sex, and if patients received the recommended medications or not. Recommended medications were defined as lipid lowering drugs, usually statins, and antiplatelets, or sometimes anticoagulants, when comorbidity indicated anticoagulation therapy.
In total, 15 810 patients had LEAD, 4 080 patients had AAA, and 2 194 patients had carotid stenosis. In all treatment groups, survival was superior for patients who used the recommended medications upon discharge. The difference was the greatest in patients with LEAD with mean survival periods of 4.33 (95% CI 4.29 – 4.36) and 3.7 (95% CI 3.64 – 3.77) years in patients discharged with and without the recommended medications, respectively (p < .001). The mean survival periods were 4.67 (95% CI 4.61 – 4.73) and 4.34 (95% CI 4.24 – 4.44) years in patients with AAA discharged with and without the recommended medications, respectively (p < .001). Cox regression analysis showed significantly lower mortality for patients discharged with the recommended medications for LEAD (HR 0.58, p < .001) and AAA (HR 0.57, p < .001).
The recommended medications were associated with improved survival in all treatment groups and both sexes. The survival difference was significant in patients with LEAD and AAA. Patients with LEAD had the greatest improvement; therefore, the recommended secondary prophylaxis is especially important in these patients.

Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.

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ABOUT THE CONTRIBUTORS

Martin Altreuther,Arne Seternes,Turi Saltnes,Nadia Myrbø,Kristin Vikan,Linn Hege Nilsen,Tingting Feng
Martin Altreuther

Section of Vascular Surgery, Department of Surgery, Trondheim University Hospital, St Olavs Hospital, Trondheim, Norway; Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway; Norwegian Registry for Vascular surgery (NORKAR), Department of Medical Quality Registries, St Olavs hospital, Trondheim University Hospital, Trondheim, Norway. Electronic address: martin.altreuther@stolav.no.

Arne Seternes

Section of Vascular Surgery, Department of Surgery, Trondheim University Hospital, St Olavs Hospital, Trondheim, Norway; Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway.

Turi Saltnes

Norwegian Registry for Vascular surgery (NORKAR), Department of Medical Quality Registries, St Olavs hospital, Trondheim University Hospital, Trondheim, Norway.

Nadia Myrbø

Norwegian Registry for Vascular surgery (NORKAR), Department of Medical Quality Registries, St Olavs hospital, Trondheim University Hospital, Trondheim, Norway.

Kristin Vikan

Norwegian Registry for Vascular surgery (NORKAR), Department of Medical Quality Registries, St Olavs hospital, Trondheim University Hospital, Trondheim, Norway.

Linn Hege Nilsen

Norwegian Registry for Vascular surgery (NORKAR), Department of Medical Quality Registries, St Olavs hospital, Trondheim University Hospital, Trondheim, Norway.

Tingting Feng

Norwegian Registry for Vascular surgery (NORKAR), Department of Medical Quality Registries, St Olavs hospital, Trondheim University Hospital, Trondheim, Norway.