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Pain General

An improved conflict avoidance assay reveals modality-specific differences in pain hypersensitivity across sexes.

Jan 29, 2024

Abnormal encoding of somatosensory modalities (ie, mechanical, cold, and heat) are a critical part of pathological pain states. Detailed phenotyping of patients' responses to these modalities have rai...

Meaningful clinical outcomes for young people and parents when treated for chronic musculoskeletal pain in the UK: Q set development.

Jan 29, 2024

Previous studies have established a core outcome set for paediatric chronic pain clinical trials. The aim of this research was to establish which outcomes young people and parents considered important...

Genomic heterozygosity is associated with a lower risk of osteoarthritis.

Jan 22, 2024

Genomic heterozygosity has been shown to confer a health advantage in humans and play a protective role in complex diseases. Given osteoarthritis (OA) is a highly polygenic disease, we set out to dete...

Skeletal muscle index together with body mass index is associated with secondary osteoporosis in patients with rheumatoid arthritis.

Jan 22, 2024

The objective of this study was to explore the associations of body mass index (BMI), fat mass index (FMI), skeletal mass index (SMI) and secondary osteoporosis (OP) in patients with rheumatoid arthri...

Effects of Savoring Meditation on Positive Emotions and Pain-Related Brain Function: A Mechanistic Randomized Controlled Trial in People With Rheumatoid Arthritis.

Jan 22, 2024

Positive emotions are a promising target for intervention in chronic pain, but mixed findings across trials to date suggest that existing interventions may not be optimized to efficiently engage the t...

Comparison of intravenous ibuprofen and paracetamol for peri-operative analgesia in paediatric day care tonsillectomy.

Jan 15, 2024

To determine the effectiveness of intravenous ibuprofen and acetaminophen as perioperative analgesics in paediatric patients undergoing day- care tonsillectomy with general anaesthesia.The quasi-exper...

Health-related quality of life and clinical outcomes for magnetically controlled growing rod patients after treatment termination.

Jan 15, 2024

To determine the health-related quality of life (HRQoL) and clinical outcomes of children with early onset scoliosis (EOS) treated with magnetically controlled growing rods (MCGR) followed to definiti...

Editorial Commentary: Artificial Intelligence Analysis of Biomedical, Large, Clinical Registry Data Using Machine Learning Requires Tens of Thousands of Subjects and a Focus on Substantial Clinical Benefit: MCID Is too Low a Bar.

Jan 15, 2024

As the field of arthroscopic hip preservation surgery grows, large high-quality registries represent a foundational study design for establishing whether hip arthroscopy is effective for patients with...

Substance P-botulinum mediates long-term silencing of pain pathways that can be re-instated with a second injection of the construct in mice.

Jan 15, 2024

Chronic pain presents an enormous personal and economic burden and there is an urgent need for effective treatments. In a mouse model of chronic neuropathic pain, selective silencing of key neurons in...

Update of statistical analysis plan for: Integration of smoking cessation into standard treatment for patients receiving opioid agonist therapy who are smoking tobacco: protocol for a randomised controlled trial (ATLAS4LAR).

Jan 08, 2024

This protocol paper presents an updated statistical analysis plan of the protocol of a randomised controlled trial. The randomised controlled trial investigates the effect of integrating smoking cessa...

Activation of ATP-sensitive potassium channels triggers migraine attacks independent of calcitonin gene-related peptide receptors: a randomized placebo-controlled trial.

Jan 08, 2024

The present study aimed to investigate whether levcromakalim, a K channel opener, induces migraine attacks in people with migraine pre-treated with erenumab, a monoclonal CGRP receptor antibody.In thi...

Switching anti-CGRP monoclonal antibodies in chronic migraine: real-world observations of erenumab, fremanezumab and galcanezumab.

Jan 08, 2024

The anti-calcitonin gene-related peptide monoclonal antibodies (anti-CGRP-mAb) are effective in migraine; however, few studies have examined the benefit of switching from one anti-CGRP-mAb to another....

The patient journey of fibromyalgia in Latin America.

Jan 08, 2024

To explore the patient journey of people with fibromyalgia (FM) in Latin American countries in order to identify problems in health care and other areas that may be resolvable.Qualitative study with p...

Imaging study of coccygeal morphology in adolescent idiopathic scoliosis.

Jan 08, 2024

The correlation between scoliosis and sagittal curvature of the cervical, thoracic, and lumbar spine have already been reported in previous studies. However, as a part of the spine, the change in cocc...

Impact of Rheumatoid Arthritis and Seropositivity on the Risk of Non-Cystic Fibrosis Bronchiectasis.

Jan 08, 2024

Despite the coexistence of bronchiectasis and rheumatoid arthritis (RA) and the poor prognosis associated with the combination of conditions, no longitudinal studies that comprehensively evaluated whe...

Cortisol as a Marker of Pain and Distress Following Acute Musculoskeletal Trauma.

Jan 08, 2024

The best available predictors of chronic pain development broadly encompass baseline metrics of cognition (i.e. beliefs/expectations) about the trauma and resulting symptoms. In the context of musculo...

ELECTROPHYSIOLOGICAL ANALYSES OF HUMAN DORSAL ROOT GANGLIA AND HUMAN INDUCED PLURIPOTENT STEM CELL-DERIVED SENSORY NEURONS FROM MALE AND FEMALE DONORS.

Jan 01, 2024

Human induced pluripotent stem cell-derived sensory neurons (hiPSC-SNs) and human dorsal root ganglia neurons (hDRG-N) are popular tools in the field of pain research; however, few groups make use of ...

Athletes and Experimental Pain: A systematic review and meta-analysis.

Jan 01, 2024

The evidence that athletes respond to and report indices of experimental pain differently to non-athlete populations was analysed. Databases screened were SPORTDiscus, PubMED, PsycArticles, the Cochra...

Knockdown of Galectin-9 alleviates rheumatoid arthritis through suppressing TNF-α-induced activation of fibroblast-like synoviocytes.

Dec 25, 2023

The role of Galectin-9 (Gal-9) in the pathogenesis of rheumatoid arthritis (RA) remains unclear. This study aimed to investigate the mechanism of action and therapeutic potential of Gal-9 in RA. We de...

Childhood trauma and the use of opioids and other prescription analgesics in adolescence and young adulthood. The HUNT Study.

Dec 25, 2023

Opioid and nonopioid analgesics are commonly prescribed to young people to alleviate pain. Even short-term prescriptions increase the risk of persistent use and future misuse of potent analgesics, suc...

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