: We aimed to determine dietary intake and serum concentration of α-tocopherol and lycopene in subjects with knee osteoarthritis (KOA) in relation to pain intensity and functional status and comparing them with healthy controls. : This case-control study was conducted among 35 patients with primary KOA and 35 matched healthy subjects selected using convenience sampling method. Dietary intakes of alpha-tocopherol and lycopene were estimated from 24-hour dietary records. Visual Analogue Scale (VAS) and Western Ontario and McMaster (WOMAC) index were used to assess the pain and functional status, respectively. : Serum concentrations of alpha-tocopherol ( = ) and lycopene ( = ) were significantly lower in OA patients in comparison with healthy controls. Dietary intake of alpha-tocopherol was negatively associated with total WOMAC score ( = = ) and pain ( = = ) and physical function ( = = ) subscales. Dietary intake of lycopene was negatively associated with total WOMAC score ( = < ) and pain ( = = ) and physical function ( = < ) subscales. Additionally, serum concentration of alpha-tocopherol was negatively associated with total WOMAC score ( = < ) and physical function subscale ( = < ). Serum concentration of lycopene was negatively associated with total WOMAC score ( = = ) and physical function subscale ( = = ) : Serum concentrations of α-tocopherol and lycopene were significantly lower in patients with KOA than in healthy controls. Significant negative association was detected between serum concentration and dietary intake of α-tocopherol and lycopene with functional disability in patients with KOA.
Lower serum levels of alpha tocopherol and lycopene is associated with higher pain and physical disability in subjects with primary knee osteoarthritis: A case-control study.
